Heparanase: a novel target of tumor metastasis therapy
نویسندگان
چکیده
منابع مشابه
Involvement of heparanase in tumor metastases: a new target in cancer therapy?
Ultimately, the cause of death for many cancer patients is the presence of metastases, the spread of the cancer from primary to distant sites. One of the critical steps in metastasis is the ability of tumor cells to degrade basement membrane structures that underlie the epithelial and endothelial cell layers, and much research has focused on the identification of genes that contribute to this p...
متن کاملHeparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
BACKGROUND Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Expression of the heparanase gene is associated with the invasive, angiogenic, and metastatic potential of diverse malignant tumors and cell lines. We used gene-silencing strategies to evaluate the role of heparanase in malignancy and ...
متن کاملHeparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.
Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. Heparanase expression is induced in carcinomas and sarcomas, often associating with enhanced tumor metastasis and poor prognosis. In contrast, the f...
متن کاملMicrowave Tumor Ablation of Vertebral Bone Metastasis: A Case Report
Introduction: Thermal ablation by microwave (MWA) has proven efficacy in treatment of primary and metastatic cancers. Soft tissue tumors could be ablated completely using MWA. However, bony tissue metastasis particularly spinal vertebral metastasis ablation has not reported yet. Case presentation: A 50 year old male patient with primary diagnosed colon cancer undergone surgical resection of ...
متن کاملOligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis.
Inhibitors of tumor angiogenesis and metastasis are increasingly emerging as promising agents for cancer therapy. Recently, heparanase inhibitors have offered a new avenue for such work because heparanase is thought to be critically involved in the metastatic and angiogenic potentials of tumor cells. Here, we report that oligomannurarate sulfate (JG3), a novel marine-derived oligosaccharide, ac...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2008
ISSN: 2219-2859
DOI: 10.11569/wcjd.v16.i4.406